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Accurate and comprehensive immunogenetic reference panels are key to the successful implementation of population‐scale immunogenomics. The 5Mbp Major Histocompatibility Complex (MHC) is the most polymorphic region of the human genome and associated with multiple immune‐mediated diseases, transplant matching and therapy responses. Analysis of MHC genetic variation is severely complicated by complex...
Genetic variation in the MICA and MICB genes located within the major histocompatibility complex region has been reported to be associated with transplantation outcome and susceptibility to autoimmune diseases and infections. Only limited data of polymorphism in these genes in different populations are available. We here report allelic variation at 2‐field resolution and the haplotypes of the MICA...
The −21 dimorphism in the leader sequences of HLA‐B exon 1 is associated with risk of graft‐versus‐host disease (GVHD), relapse and overall survival after unrelated donor hematopoietic cell transplantation (HCT), haploidentical HCT and cord blood transplantation. Consideration of the leader dimorphism in the prospective selection of allogeneic donors for HCT may help to lower risks for patients, but...
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